Beijing Puhua International Hospital

Cell Therapy Treatment Center

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Cell Therapy Treatment

Tiantan Puhua hospital uses the newest neurological approaches to provide effective and safe stem cell treatments to a wide range of neurological disorders. We Use the latest knowledge of stem cells behavior in the human body within an individually tailored medical plan according to the patient's condition. Using stem cell transplantation, intensive physiotherapy and medicines, this combination of therapies has so far proved itself to be most efficient in bringing high level of recovery to our patients. 

What are stem cells?

Stem cells are the master cells of the human body.  What define stem cells from other cells is their ability to self-generate themselves and the ability to differentiate into other cell types.

Stem cells are at the center of a new field of science called regenerative medicine. All stem cells, regardless of their source, have three general properties: they are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types.

Self-regeneration is the ability of stem cells to divide and produce more stem cells. During early development, the cell division is symmetrical i.e. each cell divides to gives rise to daughter cells each with the same potential. Later in development, the cell divides asymmetrically with one of the daughter cells produced also a stem cell and the other a more differentiated cell (such as brain cell, blood cell, etc.)

When stem cells are being transplanted into the body and arrive (through migration or through direct injection) into the injured part of the brain being targeted for tissue regeneration, the stem cells are coming into contact with growth chemicals in the body.  These chemicals program the stem cells to grow into the tissue surrounding it.

Stem cells can typically be broken into four types:

  •       Embryonic stem cells - Stem cells taken from human embryos
  •       Fetal stem cells- Stem cells taken from aborted fetal tissue
  •       Umbilical stem cells - Stem cells taken from umbilical cords
  •       Adult stem cells - Stem cells taken from adult tissue

The Type of stem cells we use

At Tiantan Puhua hospital 3 main types of stem cells are being used:

  • Neural Stem Cells (derived from fetal stem cells) used for: Cerebral Palsy,     Brain Injury, Stroke, Degenerative Diseases, and other neurological disorders.
  • hRPE Stem Cells (Adult Retinal Stem Cells) Used for: Parkinson's Disease
  • Bone Marrow Stem cells (Adult Bone Marrow stem cells extracted from the patient's own bone marrow) Recommended for young patients with a weak immune system.

What are Neural Stem Cells?

Neural Stem cells are self-regenerating, multipotent cells, found in the human brain which have the potential to differentiate into three major cell types: nerve cells (neurons), astrocytes and oligodendrocytes, and to self renew sufficiently to provide adequate number of cells in the brain.

When brain cells are damaged or are dying, due to a disease or an injury, fetal stem cells are the best known source for human neural stem cells.

Since most brain injuries, stroke, degenerative diseases and Demyelinating disorders affect several areas in the brain and not only one, the most effective and safe procedure to deliver neural stem cell into the brain is via a Lumbar Puncture (also called Spinal Tap): a spinal injection in the lumbar area (lower back) into the CSF (Cerebral Spinal Fluid).

Lumbar Puncture

During a lumbar puncture, a needle is carefully inserted into the spinal canal low in the back.  A small amount of CSF is collected, then mixed with the stem cell fluid and injected back into the CSF.

The CSF circulation (Cerebral Spinal Fluid) goes in and around the brain, separated from the blood circulation by the Blood Brain Barrier. One cycle of the CSF circulation takes between 6-7 hours. Within this time frame the stem cells will flow through the CSF into the brain.

 

 

 

 

 

The CSF circulation pathway      body position during a lumbar puncture for  stem cell injection

What are hRPE Stem Cells?

hRPE (Human Retinal Pigment Epithelial) Stem Cells, are adult multipotent stem cells that are found in the retina of the human eye. The original function of these special cells is producing Dopamine that participates in the pigmentation process inside the retina.

Due to their function, hRPE cells are a new and most promising solution for Parkinson's Patients who suffers from degeneration of their Dopamine-producing cells. Dopamine is a neuro-transmitter in our brain that supports our movement fluidity and continuity.  hRPE cells can replace degenerated dopamine-producing neurons in the nigrostriatal pathway and provide a source of increased dopamine production to promote functional recovery in Parkinson's patients.

The hRPE cells are derived from a single donor, then cultured in the laboratory to produce the amount and the type of cells fitting for implantation.

The cells are then being injected within a single operation into 4 targets in the Putamen area in the brain, using MRI 3D image guided stereotactic technique.

While the treatment can not completely remove all symptoms of the disease, it can greatly reduce the tremors, decrease muscle tension and rigidity, improve movement continuity, movement initiation and balance, increase muscle strength, improve slurred speech, reduce the freeze ups and strengthen the overall body.

Every patient who wishes to apply for this treatment should undergo
a thorough evaluation process.

For more information please read Treatment for Parkinson's or contact us.


What are Bone Marrow stem cells?

Bone marrow stem cells are the most primal cells in the marrow. From them all the various types of blood cells are descended. Stem cells from bone marrow can also, under special conditions provided in the laboratory, give rise to non-marrow cells - such as neural cells.

Bone marrow cells, unlike other types of stem cells, are available to be extracted from the patient's own body. This availability carry very significant advantages for certain medical conditions: bone marrow cells, when extracted from the patient's own body, have no risk of stimulating the immune system. This advantage is crucial when the patient's immune system is weak.

In medical conditions such as Multiple Sclerosis, certain brain infections, seizers and epileptic disorders or at any condition when the immune system is weak - bone marrow stem cell implantation will be recommended.

The procedure of Bone Marrow culturing and implantation:

On the first week upon the patient's arrival to the hospital, bone marrow is extracted from the patient's hip in a short and simple operation. This procedure is not painful and is done under a local anesthesia. The bone marrow cells are then sent to the lab and being cultures for about 3-4 weeks. In the lab, the cells are being induce into neural stem cells and then cultured to increase their number. The number of stem cells will be depending on the patient's age and the level of his bone marrow activity.  

Within a month from the bone marrow extraction, the cells will be injected back into the patients' body via lumbar puncture (spinal injection). (3-4 injections.)

Tiantan Puhua Stem cell laboratory

All stem cells used at Tiantan Puhua Hospital come directly from our hospital's own laboratory to the operating room. Our laboratory's purity standards of the cells are higher than those that are used for research. The cells are obtained from donations that are extracted by qualified hospitals and kept in cells banks (similarly to donation of other organs). The cells are then cultured in a lab before implantation.

Strict tests are performed before the cells arrive into the operating room. All stem cells used are checked for gene mutation as well as for a vast array of diseases, such as HIV, HBV, HCV, bacteria, etc. come from Sino Cells Bio Technologies Research Centre laboratories. Sino Cells Bio Technologies research center is the most renowned stem cell center in China, which holds a top level researchers team of international reputation.

 

Self Stem Cells Activation and Proliferation:
How do the stem cells survive, migrate and proliferate in the brain?

Our stem cell program includes three main elements that are working together to initiate a regeneration process in the patient's brain and functional recovery:

-          Stem cell implantation

-          Daily IV of medicines (intravenous)

-          Physical and Occupational therapy

Tiantan Puhua hospital holds the credit for a unique therapy of medicines, given through 5-7 weeks of daily IV. This formula, individually tailored for each patient's condition, aims at several targets:

  1. To prepare and enhance the microenvironment in the patient's brain, to support and protect the implanted stem cells. 
  2. To cause migration of the stem cells to the relevant areas in the brain by creating chemical signalization.  
  3. To activate inactive neural stem cell in the patient's brain, allowing them activation, proliferation and then differentiation into mature functional brain cells. 

Adult stem cells can be found in different places in our body.

Such adult stem cells are also found in our brain, residing within the periventricular subependymal zone and hippocampus. These cells are multipotent and can give rise to all three types of cells of the central nervous system. However, these stem cells are not active and are used as reserve cells. They exist in our brain as if 'sleeping', waiting for a signal that will 'wake' them into action.

With a certain combination of medicines these stem cells can be 'awaken' and start to proliferate, differentiate and produce more brain cells. 'Wakening up' these 'sleeping' neural stem cell is the main goal of the daily IV you will be receiving daily thorough the whole treatment period.  

Through several years of applying this cell therapy for a wide range of neurological disorders, this non-invasive and safe treatment has proved itself to be a highly effective for both moderate level and severe level of neurological disorders.  

Rehabilitation Center

Physiotherapy is an integral part of stem cell therapy.   The physical therapy stimulates the new cells in their process of becoming functional cells and has an important role in helping the cell migrating into the injured areas.  Our treatment program includes daily sessions of physical and occupational therapy, and as a complementary treatment  sessions of professional traditional Chinese medicine such as acupuncture and Chinese manipulation massage.    

Our rehabilitation center is placed in a short walking distance from the patients' room for an easy access. Our physiotherapists are all professionally trained and are committed to support patients through the hard work of rehabilitation and educate patients toward better mobility, functionality and recovery.

For more information about treatment for specific conditions please contact us.

One of our international department team will personally guide you through the evaluation process and signing up for the treatment. 

 

Stem Cell Treatment for Parkinson's
Stem Cell Treatment for Cerebral Palsy
Our Medical Team
Our Task and Vision
Albert Siaotong - MSA
Joaquim Violante - MSA
Anneth Swai - MSA
Namhee Chung - MSA
Voda Niculae - MSA
Parkinson???s Disease - Parkinson's Disease
Ah Chay Tan - Parkinson's Disease
Rahman Karim - Parkinson's Disease
Ah Chay Tan - Parkinson's Disease
Parkinson`s Disease - Parkinson's Disease
Niyaz Zabirov - Parkinson's Disease
Victor Stadnik - Parkinson's Disease
Mubarak Alneaimi - Parkinson's Disease
Bernard Verbaan - Parkinson's Disease
Takako Moon - Parkinson's Disease
Manfred Zimny - Parkinson's Disease
Balang Bin Kapusoh - Parkinson's Disease
Eric Kombeakali - Parkinson's Disease
Therese Lu - Parkinson's Disease
Richard Jewell - Parkinson's Disease
James Cook - Parkinson's Disease
William Bill Marquis - Parkinson's Disease
Ritha Lindell - Parkinson's Disease
Michael Smith - Parkinson's Disease
Kathleen Card - Parkinson's Disease
Linda Mckenzie - Parkinson's Disease
Ursula Kluber - Parkinson's Disease
Steve Woodward - Parkinson's Disease
Nguyen Thi Chin - Parkinson's Disease
David Budiono - Parkinson's Disease
James Devlin - Parkinson's Disease
Linda Rouen - Parkinson's Disease
David Brown - Parkinson's Disease
Jane Edwards - Parkinson's Disease
Penny Thomas - Parkinson's Disease
Gleb Kazakov - Cerebral Palsy
Anastasia Mescheryakova - Cerebral Palsy
Derek Grabast - Cerebral Palsy
Tsukimi Watanabe - Cerebral Palsy
Master Ibrahim Yousuf - Cerebral Palsy
Ke Yi Tang - Cerebral Palsy
Adrian Foon Abrahamsen - Cerebral Palsy
Anel Balayeva - Cerebral Palsy
Nathan Gil Perez - Cerebral Palsy
Jerica Elizabeth Cole - Cerebral Palsy
Abdul Azim Azhar Ali Khan - Cerebral Palsy
Attila Lawrence - Cerebral Palsy
Bianca Caprioru - Cerebral Palsy
Gabor Bocskai - Cerebral Palsy
Khaled Ahmed Al Afifi - Multiple Sclerosis
Badreddin Al Salloumi - Multiple Sclerosis
Stanislava Tapavicki - Multiple Sclerosis
Michael Darga - Multiple Sclerosis
Shayma Zuhair Ibragim - Multiple Sclerosis
Chen Li Shu - Multiple Sclerosis
Pejovic Strahinja - Batten's Disease
Aleksa Covic - Batten's Disease
Tatyanna Zazalak - Batten's Disease
Blake Dell'Aringa - Batten's Disease
Albert James De Meillon - Brain Injury
Abdulrahman Alsaadi - Brain Injury
Mark Pender - Brain Injury
Daniel Maughan - Brain Injury
Adrian Blazevic - Brain Injury
Ataxia - Ataxia
Miguel Angel - Ataxia
Kreem Izeldin Khalafalla - Ataxia
Mouayad Khalafalla - Ataxia
Joseph Pomykal - Ataxia
Tamer Saied Ahemed - Spinal Cord Injury
Steven Du Toit - Spinal Cord Injury
Cesar Sebastiao - Spinal Cord Injury
Alamemi Asem - Spinal Cord Injury
Edin Hasicic - Spinal Cord Injury
Cartaze H. Ragland - Spinal Cord Injury
Amyotrophic lateral sclerosis - ALS
Lynne Maree Negfeldt - ALS
Manana Andriadze - ALS
Yagi Masah - ALS
Hideo Tanaka - ALS
Amna Muftah EL-Shawish - ALS
Abdul Wahed - ALS
Arafat Saeed Abdulhasan Ali Fakhar - ALS
Andrew Macintosh - ALS
William Sakakura - ALS
Edgardo Antonio Escobar - ALS
Karen Brooks - ALS
Mayed Suha - Development Disorder
Sultan Saif - Development Disorder
Maather Saif - Development Disorder
Hazza Saif - Development Disorder
Tamim Jamal Algharabawi - Development Disorder
Malika Lahouaria - Development Disorder
Solvita Kadzyte - Development Disorder
Graham Edmond Leach - Other Neurological Conditions
Garry Francis Crossley - Other Neurological Conditions
Nina Tolchenova - Other Neurological Conditions
Dun Jing Wu - Other Neurological Conditions
Yahya Khaled - Other Neurological Conditions
Alexey Nechaev - Other Neurological Conditions
Cissy Ivy Bland - Other Neurological Conditions
Gorica Gavalugova - Other Neurological Conditions
Annie Gifford - Other Neurological Conditions
Richard Wiegand - PSP
Sok Lee - PSP
Wei Zhong Wang - Stroke
Cecilie Horgen - Epilepsy
Theodora Sarikouris - Epilepsy
Tareq - Diabetes
Abdullah - Diabetes
Allen Middlebrook - Diabetes
Bulan Binti Ekom - Diabetes
Miss Chen - Diabetes
Mr. Lu - Diabetes
Miss Yan - Diabetes
Ayyad - Diabetes
Mr. Luo Zheng Yong - Diabetes
Jake's CP Blog
Ove's SCI Blog
Tatyanna's Batten Blog
Kathleen's Parkinson's Blog
Linda's Parkinson's Blog
James' Parkinson's Blog
Jay's CP Blog
Arda's Brain Injury Blog
Sacha's Batten Disease Blog
Blake's Batten Disease Blog
Steve's parkinson's Blog
Dan's Brain Injury Blog
Shawna's Brain Injury Blog
Jane's Stroke Blog
Karen's ALS Blog
Shonia's CP Blog
Angela's Brain Stem Injury Blog
Chris's Brain Injury Blog
Adrian's Brain Injury Blog
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